Why Am I Always Tired? How Genetics May Be the Key to Overcoming Fatigue

Why Am I Always Tired? How Genetics May Be the Key to Overcoming Fatigue


  1. Introduction
  2. Science of Fatigue
  3. Key Genes
  4. Ste by Step Guide
  5. Conclusion

In 30 seconds...Ever feel like you're perpetually running on fumes, no matter how much sleep you get? The culprit might be more complex than you think. For instance, did you know that your TNF-alpha gene could be a chatterbox, whispering to your body to feel more tired than it should? But it's not just about your genes. Your adrenal glands might be working overtime, especially when stress enters the scene. Imagine them as two factories running low on crucial resources, leaving you feeling drained and lethargic. What you eat can also be a game-changer. The right foods can act as your secret weapon, fueling you with the energy you need to seize the day. And here's a tip: rethinking the timing of your morning coffee could be the simple tweak that prevents that dreaded afternoon slump. The real game-changer? A DNA test could unlock your personalized roadmap to boundless energy, guiding you through lifestyle choices that are tailored just for you.

Understanding Fatigue: More Than Just Being Tired

We've all had those days. You know the ones – it's the afternoon, you're seated at your desk with your eyes glazed over, staring at your computer screen as if it's written in an alien language. If you've ever found yourself sighing, "I'm tired all the time," you're not alone. In fact, you're part of a vast, yawning, worldwide tribe. But while fatigue is common, its causes and solutions are anything but. Dive with us into the fascinating study of heredity and fatigue, and see how your genes might hold the key to understanding and overcoming your tiredness.

Tiredness is like that honest friend who tells you when they've had enough – they visit, have a good time, and then with a good night's sleep, they're out the door. Fatigue, though? Fatigue is that distant relative who says they're crashing at your place for 'a couple of days' and then proceeds to make a semi-permanent home on your couch. You're now grappling with a feeling of lethargy that a hibernating bear would be proud of.

The Many Faces of Fatigue

Fatigue isn't just one-size-fits-all. Like a bad reality TV show, it comes in various types, each more intriguing and frustrating than the last. Physical fatigue makes your body feel like it's been hit by a truck. Mental fatigue turns your brain into a bowl of overcooked spaghetti. And don't even get me started on chronic fatigue syndrome, which combines all the fun of both.

And then there are the symptoms. Are you always cold and tired? Do you have a recurring sore throat and fatigue? Do you feel extreme mid-afternoon fatigue that makes you want to curl up under your desk? And sometimes, fatigue brings along its plus one – a recurring sore throat, just to keep things interesting. It's that unexpected twist in the plot, the surprise element in what was supposed to be a routine day. Fatigue can manifest in many ways, but they all result in the same thing: you, feeling like an exhausted zombie.

Genetics and Fatigue: The Study of Heredity

Is fatigue heredity? Remember the last time you wondered, "Why am I constantly tired all the time?" Well, your genes might have something to do with it. We're endlessly fascinated by the study of heredity. Your genes, like a gripping novel or a binge-worthy series, have a captivating tale to narrate. Genes are those tiny building blocks of life, can be real chatterboxes when you know how to listen. And sometimes, they're talking about why you're always tired.

It turns out; your constant yawning could have something to do with your genes - including but not limited to the TNF gene, IL-6 gene, COMT gene, HLA gene. These aren't obscure passwords for a sci-fi game or classified blueprints for next-gen robots, but your very own genes that might be contributing to your fatigue.

The Usual Suspects: Key Genes Associated with Fatigue

When it comes to fatigue, several genes stand out from the crowd. They're like the Usual Suspects of the genetics world, but instead of causing mischief, they influence how we experience fatigue.

Here's a brief breakdown of each key gene and its connection to fatigue:

TNF-alpha Gene

First up, we have TNF-alpha. This gene is a bit like the grumpy neighbour who complains when your music is too loud. It's involved in inflammation in the body, which, when out of balance, can lead to a sense of fatigue. Some variants of this gene have been associated with increased levels of inflammation, which may lead to heightened feelings of fatigue.

IL-6 Gene

Next in our line-up is IL-6. This gene is also involved in inflammation and immune response. Some studies suggest that variations in the IL-6 gene may influence susceptibility to fatigue, particularly in conditions such as chronic fatigue syndrome.


Then we have COMT, a gene that's involved in breaking down certain chemicals in the brain, including dopamine, a neurotransmitter that plays a crucial role in motivation and reward. Some variants of the COMT gene can affect dopamine levels, which may influence energy levels and susceptibility to fatigue.

HLA Genes

The HLA genes are a complex group of genes involved in immune system function. Certain variants of these genes have been associated with conditions like chronic fatigue syndrome, suggesting a potential genetic predisposition towards fatigue in some individuals.

Serotonin-related genes

Finally, we have serotonin-related genes. Serotonin is a neurotransmitter that helps regulate mood, sleep, and other functions. Changes in serotonin levels have been linked to feelings of fatigue, and certain gene variants may influence how your body produces and uses this important chemical.

These are your personal genes, potentially contributing to your fatigue. They could be the reason why you're constantly yearning for a siesta. But don't worry, once we crack this genetic code, we're a step closer to devising your customized roadmap to enhanced energy and reduced fatigue.

When Your Body Gets Overzealous: The Tale of Adrenal Fatigue & Low DHEA

Adrenal fatigue is like that sneaky character in a mystery novel – it keeps you guessing and throws you off your game. Picture your adrenal glands as two busy factories nestled above your kidneys, dutifully producing hormones that keep your energy levels in check.

These diligent factories are designed to handle the everyday hustle and bustle, but when stress enters the scene - like an unscheduled shipment of orders - they can go into overdrive. Like any production line faced with overtime and high demand, the adrenal glands can end up feeling overworked and underappreciated.

One of the key players in this hormonal production is DHEA, a hormone your body utilises as a versatile raw material. DHEA is like the all-star employee, contributing to the production of other hormones like cortisol and Estrogen. However, when you're low on DHEA, it's like the factories are running low on their most crucial resource.

Imagine trying to bake a cake without flour or build a car without steel - it's going to be a tough task. Similarly, when your body is low on DHEA, it's like trying to keep your hormonal balance with a key ingredient missing. But don't worry, understanding this is half the battle won. The next step is figuring out how we can restock these hormonal factories and get them back to their peak performance.

A Step-by-Step Guide to Combat Fatigue

And now, the climax you've been patiently scrolling towards! A clear step-by-step strategy to transition from "Why am I always ready for a nap?" to "I'm brimming with more energy than a high-voltage power line!" You know the saying, "Knowledge is power?" Well, when it comes to fatigue, knowledge is energy. Understanding your genes and how they may contribute to your fatigue is the first step. The next step? Taking action. Here is a quick guide on how to combat fatigue + a cheeky tip backed by science afterwards…

Nutrition: Your Fatigue-Fighting Foundation

When it comes to fighting fatigue, consider nutrition your secret weapon. It's like the superhero of your wellness journey, swooping in to save the day when your energy levels start to dip.

Think of your body like a high-performance car. If you want it to run smoothly, you need to fill it with the right kind of fuel. And that's where nutrient-rich foods come into play.

Eat the Rainbow

Try to incorporate a variety of fruits and vegetables into your diet. These colourful characters pack a powerful nutritional punch, providing a wealth of vitamins, minerals, and antioxidants that can help to boost your energy levels. For instance, bananas are high in potassium, which can help to prevent muscle weakness and fatigue.

Protein Power

Don't forget about protein. Foods like lean meat, poultry, fish, eggs, and legumes are excellent sources of protein, which is crucial for maintaining muscle mass and promoting feelings of fullness, preventing the energy crashes that can come after eating high-sugar foods.

Complex Carbohydrates

Complex carbohydrates are also key. Foods such as whole grains, brown rice, and sweet potatoes release energy slowly, keeping your energy levels stable and preventing the dreaded mid-afternoon slump.

Stay Hydrated

And let's not forget about hydration. Even mild dehydration can lead to feelings of fatigue, so make sure you're drinking plenty of water throughout the day. If you're feeling adventurous, try adding a slice of lemon for a citrusy twist.

Consistency is Key

Lastly, try to maintain a regular eating schedule. Skipping meals can lead to drops in blood sugar, which can leave you feeling weak and tired. Regular, balanced meals can help to keep your energy levels stable throughout the day.

Remember, the best diet for low energy is a balanced one. Incorporating a variety of nutrient-rich foods into your diet can help to fight fatigue and keep your energy levels high. After all, food is not just fuel - it's information for your genes.

Supplementing Energy: Give Your Genes a Boost

Sometimes, despite our best efforts, our diets might not provide us with all the nutrients we need to combat fatigue. This is where supplements can swoop in like a super-sub on a football pitch, filling in the gaps and giving us an extra boost.

Depending on your unique genetic profile, you might find certain supplements particularly beneficial. Remember, our bodies are as unique as our fingerprints (or our Netflix watch lists), so what works for one person might not work for another.

B Vitamins

B vitamins, for example, are like the 'Energizer Bunny' of the nutrient world. They play a crucial role in helping our bodies convert food into energy. B12, in particular, is known for its role in preventing tiredness and weakness.


Iron is another essential supplement for combating fatigue, particularly if you're someone who experiences heavy periods, is pregnant, or follows a vegan or vegetarian diet. Iron is crucial for making hemoglobin, a protein in your red blood cells that carries oxygen around your body. Low levels can lead to iron deficiency anemia, a common cause of fatigue.

CoQ10 and L-arginine

Coenzyme Q10, or CoQ10 for short, is a substance that helps generate energy in your cells. It's somewhat like a spark plug for your body, and a deficiency in CoQ10 can often result in feeling low on energy.

L-arginine, an amino acid, is another supplement that can be beneficial for fatigue. It helps your body build protein and can be converted into a molecule called nitric oxide, which widens blood vessels and improves blood flow, potentially enhancing energy levels.


Magnesium is another fatigue-fighter. It's involved in hundreds of reactions in your body, including energy creation. Some research suggests that even marginal magnesium deficiency can lead to increased levels of fatigue.

Adrenal Support

If your genetic profile shows you might be more susceptible to adrenal fatigue, certain supplements could be beneficial. For example, vitamins B5, B6, and C are often recommended for supporting adrenal gland function. Certain herbs, like Ashwagandha and Rhodiola, have also been used traditionally to support adrenal health and combat fatigue.

And if you're wondering how to figure out which supplements might be beneficial for you? Dont go shooting in the dark, our DNA Test uncovers your vitamin & mineral blueprint DNA & Epigenetic Health Test.

Before you start adding these supplements to your online shopping cart, remember this golden rule: Always consult a healthcare provider before starting any new supplement regimen. They can help ensure any supplements you take are safe and appropriate for your specific health needs and genetic profile.

Exercise to Overcome Fatigue

We get it. When you're feeling tired, the last thing you want to do is don a pair of running shoes and hit the pavement. But here's the thing: regular exercise is one of the most effective ways to boost your energy levels. It's a bit like a biological elevator – it might require some energy to get started, but once you're on it, it lifts you up.

The Science Behind Exercise and Energy

Exercise improves the efficiency of your heart, lungs, and muscles – the powerhouse trio involved in producing energy. It also stimulates the production of endorphins, your body's natural mood boosters, which can leave you feeling more energised and alert.

Finding Your Ideal Exercise Regime

The key is to find a form of exercise you enjoy. You don't have to transform into a marathon runner overnight. Even moderate activities, like a brisk walk in the park or a lunchtime yoga session, can help boost your energy levels.

If you're into team sports, joining a local club can be a great way to incorporate regular exercise into your routine. For those who enjoy a solitary sweat session, a solo run, bike ride, or HIIT workout could be just the ticket.

And remember, variety is the spice of life – and exercise. Mixing up your routine can keep things interesting and ensure you're working different muscle groups.

Listening to Your Body

While exercise is a potent fatigue-fighter, it's crucial to listen to your body. It's normal to feel tired after a vigorous workout, but if you're feeling extremely tired after exercise, it might be time to reassess. Are you pushing yourself too hard? Not giving your body enough time to recover?

Overtraining can lead to increased fatigue, reduced performance, and even injury. So, ensure you're striking a balance between activity and rest. Consider consulting a healthcare provider or fitness professional to help tailor a workout regime that suits your individual needs, fitness levels, and genetic profile.

Lifestyle Choices

Good sleep hygiene, stress management, and regular medical check-ups are key to combating fatigue. Always listen to your body - if you're feeling very weak and tired, it might be a sign that you need to slow down and take care of yourself.

The Caffeine Curveball: The Power of Postponing Your First Coffee

Ah, coffee. That magical brew that seems to have the power to transform us from sleep-deprived zombies into fully functioning humans. But did you know that the timing of your first cup of coffee can make a big difference in how you feel throughout the day? This idea comes from none other than neuroscientist Andrew Huberman.

According to Andrew Huberman, having your first coffee immediately after waking up might not be the best strategy if you're looking to avoid that dreaded afternoon crash. Instead, he suggests waiting about 90 minutes after you wake up before having your first coffee.

Here's why
When you wake up, your body naturally produces cortisol, a hormone that helps you feel alert and awake. If you consume caffeine right away, you're not really giving your body a chance to wake up naturally. Instead, you're kind of forcing it to be alert by introducing caffeine.

But there's a catch. Caffeine has a half-life of around five to six hours, meaning that after this time, half of the caffeine is still in your system. So, if you're having a coffee first thing in the morning, by the time mid-afternoon rolls around, the effects of the caffeine are wearing off, and you're likely to experience a 'caffeine crash'.

By waiting 90 minutes to have your coffee, you're allowing your body to wake up naturally with the help of cortisol. Then, when the effects of cortisol start to wear off, that's when you introduce caffeine. This way, the caffeine carries you through the day, preventing the afternoon crash.

It's a simple change, but it could make a big difference in your energy levels throughout the day. So, tomorrow morning, instead of reaching for the coffee pot as soon as you wake up, why not try waiting a bit? Your afternoon self will thank you!

Genetic Health Tests

You don't have to fight fatigue alone. Genetics could hold the key to why you might be feeling fatigued or personalised health solutions on how to optimise your nutrition to maximise energy. Starting with our DNA Health Test to discover your blueprint or jumping straight into our comprehensive DNA & Epigenetic health tests. By combining your genetic data with your lifestyle information, we can provide personalised nutrition, exercise, and supplement recommendations to help manage fatigue.

If you want to learn more, or see which is the best genetic health test for you, check out our website It's time to stop merely surviving and start f*cking nailing it.