Personalised Supplements & Genetics: 7 Must-Know Genes that Influence Nutrient Absorption

Personalised Supplements & Genetics: 7 Must-Know Genes that Influence Nutrient Absorption


  1. Introduction
  2. Personalised Supplements
  3. 7 Must-Know Genes
  4. DNA Health Test
  5. Conclusion


In the age of personalised nutrition, the question on everyone's lips is, "Which supplements should I take daily?" With the rise of DNA and epigenetic health tests, we're now able to tailor our supplement intake based on our unique genetic makeup. But how exactly do our genes influence the supplements we should be taking? Let's dive deep into the world of genetics and discover the key players that determine our nutrient needs.

What Are Personalised Supplements

The concept of personalised vitamins is not just a trend; it's a scientific approach to nutrition. Every individual has a unique genetic code that influences how they absorb, metabolise, and utilise nutrients. This means that while one supplement might work wonders for one person, it might be less effective or even unnecessary for another.

  • Are supplements a waste of money? Not if they're tailored to your genetic needs.
  • Are supplements good for you? Absolutely, when they align with your genetic blueprint.

With the increasing interest in personalised vitamins UK, it's clear that the nation is catching on to the benefits of tailored nutrition. But to truly understand the power of personalised supplements, we need to delve into the specific genes that play a pivotal role.

7 Must-Know Genes That Influence Nutrition

1. Vitamin D and the VDR Gene

Vitamin D, often dubbed the 'sunshine vitamin', is crucial for bone health, immune function, and mood regulation. But did you know that your ability to utilise vitamin D is influenced by the VDR (Vitamin D Receptor) gene?

  • How it works: The VDR gene affects how your body responds to vitamin D. Variants in this gene can influence how effectively your body uses the vitamin, potentially leading to deficiencies even if you're getting enough sun or dietary intake.
  • Solution: If you have certain VDR variants, you might benefit from higher doses of vitamin D supplements or more frequent intake.

2. Fats, Cholesterol, and the APOE Gene

When considering what supplements should I take, it's essential to understand your body's fat metabolism. Enter the APOE gene, which plays a significant role in how your body processes fats and cholesterol.

  • How it works: Different variants of the APOE gene can influence your risk of heart disease, how you metabolise dietary fats, and even your response to omega-3 supplements.
  • Solution: Omega-3 supplements, particularly those rich in EPA and DHA, can be beneficial, especially for individuals with specific APOE variants.

3. Choline, Brain Health, and the PEMT Gene

Ever wondered what supplements lower cortisol or boost brain health? Choline might be the answer, and its metabolism is influenced by the PEMT gene.

  • How it works: The PEMT gene plays a role in choline production, a nutrient vital for brain health, liver function, and even stress management.
  • Solution: Phosphatidylcholine or Alpha-GPC supplements can be beneficial, especially for those with certain PEMT gene variants that might predispose them to choline deficiency.

4. From Plants to Vision: The BCMO1 Gene

Beta-carotene, found abundantly in carrots and sweet potatoes, is a precursor to vitamin A. But how efficiently your body converts it is determined by the BCMO1 gene.

  • How it works: Variants in the BCMO1 gene can reduce the efficiency of this conversion, meaning you might not be getting as much vitamin A from plant sources as you think.
  • Solution: A direct vitamin A supplement, like retinyl palmitate or retinyl acetate, might be more effective for those with specific BCMO1 variants.

5. Omega Fatty Acids and the FADS1 & FADS2 Genes

The balance of omega-3 and omega-6 fatty acids is crucial for heart health, brain function, and inflammation control. The FADS genes play a pivotal role in how your body processes these fats.

  • How it works: Variants in these genes can influence your body's conversion of plant-based omega-3s, like ALA, into the more active forms, EPA and DHA.
  • Solution: Those with certain FADS variants might benefit more from fish oil supplements, which provide direct sources of EPA and DHA.

6. Iron Overload and the HFE Gene

Iron is vital for energy production and oxygen transport, but too much can be harmful. The HFE gene can influence your risk of absorbing excessive amounts.

  • How it works: Mutations in the HFE gene can lead to hemochromatosis, a condition where the body absorbs too much iron.
  • Solution: Individuals with certain HFE mutations should be cautious with iron supplements and might benefit from regular blood tests to monitor iron levels.

7. Antioxidants, Oxidative Stress, and the SOD2 Gene

Oxidative stress is a buzzword in the health community, and for a good reason. It's linked to ageing, inflammation, and various diseases. The SOD2 gene plays a role in your body's defence against oxidative stress.

  • How it works: This gene influences the production of a key antioxidant enzyme, superoxide dismutase 2.
  • Solution: Antioxidant-rich supplements, like astaxanthin or coenzyme Q10, can be beneficial, especially for those with specific SOD2 variants.

Bonus Gene: Blood Pressure, Electrolytes, and the ACE Gene

Lastly, the ACE gene, which plays a role in blood pressure regulation, can influence your body's response to certain minerals.

  • How it works: Variants in the ACE gene can affect blood pressure responses to potassium and sodium.
  • Solution: Depending on one's ACE gene variant, a tailored intake of potassium-rich supplements or a reduced sodium intake might be recommended.

Personalised Supplements & Genetics: UK Perspective

The trend of personalised supplements in the UK is not merely a passing phase; it's a reflection of the profound influence of genetics on our health decisions. With the advancements in DNA and epigenetic health tests, we're now empowered to delve deeper into our unique genetic blueprint. This allows us to confidently address the question, "Are personalised vitamins worth it?" with an unequivocal affirmation. By aligning our supplement choices with our genetic predispositions, we're ensuring optimal nourishment tailored precisely to our individual needs.


In the realm of personalised nutrition, understanding our genes is the key to unlocking optimal health. With advances in DNA and epigenetic health tests, we're now more equipped than ever to make informed decisions about our supplement intake. So, the next time you find yourself wondering, "What supplements should I take daily?", remember that the answer lies in your DNA.

The information provided in this article is for informational purposes only and is not intended as medical advice, diagnosis, or treatment. It should not be used as a substitute for professional medical advice or care. Always consult with a qualified healthcare professional before making any changes to your diet, supplement regimen, or health practices. The author and publisher disclaim any liability or responsibility arising from any injury, harm, or damage, to any individual or entity as a result of the use, application, or interpretation of the content presented.

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